Journal
TRENDS IN CELL BIOLOGY
Volume 15, Issue 1, Pages 43-51Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2004.11.009
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Funding
- NCRR NIH HHS [RR 00592] Funding Source: Medline
- NIGMS NIH HHS [GM 61306] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR000592] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM061306] Funding Source: NIH RePORTER
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The most important goal of structural cell biology is to elucidate the mechanisms of the processes of life. The structure of a membrane system or fibrous array, the changes in such structures over time or the localizations of enzymes relative to organelle boundaries can often illuminate associated cellular functions. To be of maximal value, structural studies should provide isotropic, 3D information about well-preserved samples at the highest possible resolution. Electron tomography can provide such information about many kinds of cells and organelles.
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