Journal
AAPS JOURNAL
Volume 7, Issue 3, Pages E592-E599Publisher
SPRINGER
DOI: 10.1208/aapsj070361
Keywords
kappa; opioid; self-administration; stimulant
Categories
Ask authors/readers for more resources
Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the dopamine hypothesis has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor in mediating the abuse effects. Therefore, most treatments have focused on directly influencing the dopamine system. Another approach, which has been explored for potential treatments of stimulant abuse, is the use of kappa opioid agonists. The k receptor is known to be involved, via indirect effects, in synaptic dopamine levels. This review covers several classes of k opioid ligands that have been explored for this purpose.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available