Journal
E-JOURNAL OF SURFACE SCIENCE AND NANOTECHNOLOGY
Volume 3, Issue -, Pages 203-206Publisher
SURFACE SCI SOC JAPAN
DOI: 10.1380/ejssnt.2005.203
Keywords
Ion channels; Tethered lipid bilayers; Impedance spectroscopy; Biophysics; Electrical transport; Self-assembly; Biosensing and devices; Biological aspects of nanostructures
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The efficient analysis of the function of ion channels is an important task in many different fields ranging from (bio) analytics and drug-screening to nanoelectronics. Here, the modulation of the channel activity of a synthetic ligand gated ion channel by a specific antibody is measured in tethered lipid bilayers by impedance spectroscopy. Tethered single lipid bilayers with exceptionally high electrical resistances suitable for the detection of a few channels are presented.
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