Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 16, Issue 7, Pages 320-326Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2005.07.005
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Funding
- NICHD NIH HHS [HD20788, U54-HD31398] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [U54HD031398, R01HD020788] Funding Source: NIH RePORTER
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The epidermal growth factor (EGF) network is composed of a complex array of growth factors synthesized as precursors and expressed on the cell surface. These latent growth factors are activated by cleavage and shedding from the cell surface and act by binding to various homo- and hetero-dimers of the EGF receptors (ErbBs). Although the exact molecular steps are poorly understood, ligand binding to G-protei n-coupled receptors as diverse as the beta-adrenoceptors or the lysophosphatidic acid receptors leads to shedding of EGF growth factors and activation of EGF receptors. Recent observations from the pituitary and in the ovary are providing new insight into the role of this network in endocrine systems.
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