Journal
CARBON
Volume 55, Issue -, Pages 343-349Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2012.12.074
Keywords
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Funding
- Natural Science Foundation of China [21275027, 21235001, 21075013]
- Program of New Century Excellent Talents in University [NCET-11-0071]
- Fundamental Research Funds for the Central Universities [N110705002, N110405005, N110805001]
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A cationic branched polyelectrolyte of large molecular weight, i.e., polyethylenimine (PEI) of 25,000 Da, was used as both a carbon source and a passivating agent to prepare photoluminescent carbon nanoparticles (CNPs) in one step. In contrast to the previously reported pH-insensitive CNPs, these CNPs have a distinct pH-sensitive feature that gives them the potential to serve as a proton sensor in monitoring cell metabolization process with proton release. When incubated with HeLa cells, the CNPs could readily penetrate the cell membrane and exhibit low cytotoxicity and favorable biocompatibility. The CNPs have been used for HeLa cell imaging. (C) 2012 Elsevier Ltd. All rights reserved.
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