Journal
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
Volume 15, Issue 1, Pages 33-41Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/BIP-200040809
Keywords
AR(1); compound symmetry; independent working correlation; monotone missing
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Funding
- NCRR NIH HHS [M01RR02588] Funding Source: Medline
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Sample size calculation is an important component at the design stage of clinical trials. We investigate the implications of dropouts for the sample size estimates in testing differences in the rates of changes produced by two treatments in a randomized parallel-groups repeated measurement design. Statistical models for calculating sample sizes for repeated measurement designs often fail to take into account the impact of dropouts correctly. In this article, we examine the impact of dropouts on sample size estimate and compare the power with the approach of Jung and Ahn [Jung, S. H., Ahn, C. (2003). Sample size estimation for GEE method for comparing slopes in repeated measurements data. Stat. Med. 22: 1305-1315] with that suggested by Patel and Rowe [Patel, H., Rowe, E. (1999). Sample size for comparing linear growth curves. J. Biopharm. Stat. 9:339-350] through a simulation study.
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