Journal
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
Volume 15, Issue 2, Pages 343-351Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/BIP-200048798
Keywords
correlated responses; dose response analysis; in vivo assays; nonlinear regression; potency estimation
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The analysis of dose-response assays measuring two correlated responses is considered. Attention is given to statistical inference for the potency ratio. Results from a simulation study suggest that a post hoc adjustment for the correlation in parameter estimates obtained from univariate fits provides nearly as much power to detect differences in potency as a bivariate response model fit.
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