Journal
JOURNAL OF NEUROIMAGING
Volume 15, Issue 4, Pages 46S-57SPublisher
WILEY
DOI: 10.1177/1051228405284200
Keywords
magnetic resonance spectroscopy; multiple sclerosis; N-acetylaspartate; choline; creatine; myo-inositol; metabolite; magnetic resonance imaging; axonal damage; atrophy
Funding
- NIBIB NIH HHS [R01 EB002095] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002095] Funding Source: NIH RePORTER
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In addition to providing information on tissue structure, magnetic resonance (MR) technology offers the potential to investigate tissue metabolism and function. MR spectroscopy (MRS) offers a wealth of data on the biochemistry of a selected brain tissue volume, which represent potential surrogate markers for the pathology underlying multiple sclerosis (MS). In particular, the N-acetylaspartate peak in an MR spectrum is a putative marker of neuronal and axonal integrity, and the choline peak appears to reflect cell-membrane metabolism. On this basis, a diminished N-acetylaspartate peak is interpreted to represent neuronal/axonal dysfunction or loss, and an elevated choline peak represents heightened cell-membrane turnover, as seen in demyelination, remyelination, inflammation, or gliosis. Therefore, MRS may provide a unique tool to evaluate the severity of MS, establish a prognosis, follow disease evolution, understand its pathogenesis, and evaluate the efficacy of therapeutic interventions, which complements the information obtained from the various forms of assessment made by conventional MR imaging.
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