Journal
CARBON
Volume 49, Issue 5, Pages 1797-1805Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2011.01.003
Keywords
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Funding
- National Natural Science Foundation of China [20735004, 20875089]
- State Key Basic Research Development Program of China (973 Program) [2005CB522701]
- Dalian Institute of Chemical Physics
- National High Technology Research and Development Program of China (863 Program) [2008AA02Z211]
- Chinese Academy of Sciences
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A nanomaterial, folate and iron difunctionalized multiwall carbon nanotube (FA-MWCNT@Fe), has been synthesized by conjugating folate and iron nanoparticles with oxidized multi-walled carbon nanotubes, and applied as a dual-targeted drug nanocarrier to deliver doxorubicin into HeLa cells with the assistance of an external magnetic field. The prepared FA-MWCNT@Fe was characterized by X-ray diffraction, transmission electron microscopy and infrared spectroscopy. This nanocarrier has a sufficient load capacity (doxorubicin/FA-MWCNT@Fe, 32 mu g/mg) and a prolonged release property controlled by near infrared radiation. It also demonstrated both biologically (active) and magnetically (passive) targeting capabilities toward HeLa cells in vitro with ca. 6-fold higher delivery efficiency of doxorubicin than free doxorubicin. (C) 2011 Elsevier Ltd. All rights reserved.
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