Journal
EUROPEAN JOURNAL OF MASS SPECTROMETRY
Volume 11, Issue 3, Pages 325-333Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1255/ejms.745
Keywords
electrospray; MS/MS; benzylisoquinoline alkaloids; atmospheric pressure photoionization; mass spectral fragmentation
Ask authors/readers for more resources
Benzylisoquinoline alkaloids found in the Papaveraceae family play a major role in pharmaceutical biology. This is the first systematic study dealing with electrospray tandem mass spectrometry (ESI-MS/MS) of all benzylisoquinolines found as biogenetic precursors of morphinan alkaloids. Tandem mass spectral data are presented for norlaudanosoline, laudanosoline, 4'-O-methyl-norlaudanosoline, 6-O-methyl-norlaudanosoline, norcoclaurine, coclaurine, N-methylcoclaurine, N-methyl-3'-hydroxycoclaurine, N-methyl-3'-O-methylcoclaurine, norreticuline and reticuline. This study compares results obtained using an ion trap mass spectrometer with those obtained using a triple quadrupole one. The results highlight the differences between the tandem-in-time versus the tandem-in-space principle, often hampering the development of ESI-MS/MS libraries. In addition, the use of the atmospheric pressure photoionisation technique for the analysis of such substances is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available