Journal
CELLS TISSUES ORGANS
Volume 179, Issue 1-2, Pages 66-72Publisher
KARGER
DOI: 10.1159/000084510
Keywords
hyaluronan; antiapoptotic signaling; ErbB2; beta-catenin; multidrug resistance
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Hyaluronan plays a central role in the transition of epithelia to mesenchyme in the embryo and in the acquisition of transformed properties in carcinoma cells. In some cases, hyaluronan is both essential and sufficient for induction of epithelial-mesenchymal transitions (EMTs). Underlying its role are the effects of hyaluronan on receptor kinase activities, cell survival pathways, and multidrug transporters. A more complete understanding of the mechanisms whereby hyaluronan exerts its influences on cell behavior will enhance our understanding of normal and pathological EMTs and may lead to improved therapies for cancer patients. Copyright (C) 2005 S. Karger AG, Basel.
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