Journal
MASS SPECTROMETRY REVIEWS
Volume 24, Issue 5, Pages 701-718Publisher
WILEY
DOI: 10.1002/mas.20035
Keywords
aging; proteomics; protein oxidation; post-translational modifications
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Funding
- NATIONAL INSTITUTE ON AGING [P01AG012993] Funding Source: NIH RePORTER
- NIA NIH HHS [P01AG12993] Funding Source: Medline
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This review covers the application of mass spectrometric techniques to aging research. Modern proteomic strategies will be discussed as well as the targeted analysis of specific proteins for the correlation of post-translational modifications with protein function. Selected examples will show both the power and also current limitations of the respective techniques. Experimental results and strategies are discussed in view of current theories of the aging process. (c) 2004 Wiley Periodicals, Inc.
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