Journal
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Volume 26, Issue 3, Pages 247-255Publisher
SPRINGER
DOI: 10.1007/s00281-004-0174-2
Keywords
cytotoxic T lymphocyte; CD8(+) T cell; vaccine; dendritic cell; antigen presentation
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI058743, P01AI040682, K08AI052406] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI40682, AI52406, AI58743] Funding Source: Medline
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Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.
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