Journal
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Volume 18, Issue 4, Pages 673-688Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2005.01.024
Keywords
neurologic complications; peripheral neuropathy; multiple myeloma; Waldenstrom; macroglobulinemia; cryoglobulinemia; amyloidosis; POEMS syndrome; MGUS
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Funding
- NATIONAL CANCER INSTITUTE [P01CA062242] Funding Source: NIH RePORTER
- NCI NIH HHS [CA62242] Funding Source: Medline
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The spectrum of neurologic complications of multiple myeloma (MM) and related conditions is as diverse as the conditions themselves. Complications range from direct compression (radiculopathy, spinal cord compression, base-of-the-skull tumor) to the infiltrative (amyloid, peripheral neuropathies, and numb chin syndrome of myeloma), the metabolic (slowed mentation from hyperviscosity, hypercalcemia, or uremia), and to autoimmune or cytokine-mediated (peripheral neuropathy). The two most common presentations are the compressive radiculopathy one sees in multiple myeloma and the peripheral neuropathies associated with many of the other disorders. The authors will review the neurologic complications of MM, monoclonal gammopathy of undetermined significance (MGUS), Waldenstrom macroglobulinemia (WM), POEMS syndrome, amyloidosis, and cryoglobulinemia.
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