4.5 Article

Total synthesis of the bacillosamine containing α-L-serine linked trisaccharide of Neisseria meningitidis

Journal

CARBOHYDRATE RESEARCH
Volume 399, Issue -, Pages 57-63

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2014.04.011

Keywords

Neisseria meningitides; Stereoselective glycosylation; Aminoacid coupling; Rare sugars; Nucleophilic displacement of triflates

Funding

  1. Department of Science and Technology [SR/S1/OC-40/2009]
  2. Council of Scientific and Industrial Research [01(2376)/10/EMR-II]
  3. CSIR-New Delhi

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Total synthesis of the bacillosamine containing L-serine linked O-trisaccharide of Neisseria meningitidis is described. The synthesis entails installation of two consecutive alpha-linkages including the coupling of bacillosamine with L-serine derivative. (C) 2014 Elsevier Ltd. All rights reserved.

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