Journal
CARBOHYDRATE RESEARCH
Volume 356, Issue -, Pages 12-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2012.02.027
Keywords
Lipopolysaccharide; O-Polysaccharide; ATP-binding cassette transporter; Escherichia coli O9a; Klebsiella pneumoniae O2a
Funding
- Natural Sciences and Engineering Research Council
- Canadian Institutes of Health Research
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The O-polysaccharide (O-PS; O-antigen) of bacterial lipopolysaccharides is made up of repeating units of one or more sugar residues and displays remarkable structural diversity. Despite the structural variations, there are only three strategies for O-PS assembly. The ATP-binding cassette (ABC)-transporter-dependent mechanism of O-PS biosynthesis is widespread. The Escherichia coli O9a and Klebsiella pneumoniae O2a antigens provide prototypes, which are distinguished by the fine details that link glycan polymerization and chain termination at the cytoplasmic face of the inner membrane to its export via the ABC transporter. Here, we describe the current understanding of these processes. Since glycoconjugate assembly complexes that utilize an ABC transporter-dependent pathway are widespread among the bacterial kingdom, the models described here are expected to extend beyond O-PS biosynthesis systems. (C) 2012 Elsevier Ltd. All rights reserved.
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