Journal
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
Volume 11, Issue 4, Pages 295-302Publisher
WILEY-LISS
DOI: 10.1002/mrdd.20084
Keywords
knock-out; conditional knock-out; Cre recombinase; inducible systems; mouse models
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Funding
- NICHD NIH HHS [P30 HD15052] Funding Source: Medline
- NIMH NIH HHS [R01 MH 45507] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD015052] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH045507] Funding Source: NIH RePORTER
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The human and mouse genome projects elucidated the sequence and position map of innumerous genes expressed in the central nervous system (CNS), advancing our ability to manipulate these sequences and create models to investigate regulation of gene expression and function. In this article, we reviewed gene targeting methodologies with emphasis on applications to CNS development and neurodevelopmental disorders. (c) 2005 Wiley-Liss, Inc.
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