Probing β-(1→3)-D-glucans interactions with recombinant human receptors using high-resolution NMR studies

A full characterization of the high-resolution NMR spectrum of the laminarihexaose is described and used for the determination of the binding epitope of the more complex but structurally related laminarin. These biophysical data extend the current knowledge of beta-glucans/Dectin-1 interactions and suggest different biological mechanisms in close relation with the size of the saccharidic chain. (C) 2011 Elsevier Ltd. All rights reserved.