Journal
CARBOHYDRATE RESEARCH
Volume 346, Issue 12, Pages 1564-1568Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2011.04.044
Keywords
Propargyl glycosides; Click chemistry; Hydroxyapatite; Biomaterials; Lectin
Funding
- MIUR [FIRB RBPO68JL9]
- FONDAZIONE CARIPLO [2008/3175]
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An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented: the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which alpha-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins. (C) 2011 Elsevier Ltd. All rights reserved.
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