Journal
CARBOHYDRATE RESEARCH
Volume 345, Issue 5, Pages 709-714Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.12.028
Keywords
Triterpene glycosides; Anti-inflammatory activity; Cyclamen repandum
Funding
- M.I.U.R
Ask authors/readers for more resources
A new triterpene glycoside, repandoside (1) was isolated together with six known saponins (2-7) from the methanol extract of Cyclamen repandum tubers. The isolated saponins were characterized by high resolution mass spectrometry and both 1D and 2D NMR experiments. The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 mu M inhibited the LPS-induced IL-8 and TNF-alpha expressions. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available