Journal
CARBOHYDRATE RESEARCH
Volume 345, Issue 10, Pages 1280-1282Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.04.012
Keywords
Biomarker; Glycomics; High-throughput; Serum N-glycans
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Glycomics has been proven to be challenging when compared to genomics, transcriptomics, or proteomics. Understanding glycans is difficult as they have a non-template driven biosynthesis and their structural characterization requires highly efficient techniques. This review will describe the robotic platform developed in our laboratory for high-throughput analysis of N-glycans, and some of the advances obtained in the Glyco-biomarker field obtained in the last three years, including the first Genome-Wide Association Study showing a direct link between DNA polymorphisms and glycosylation. (C) 2010 Elsevier Ltd. All rights reserved.
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