Journal
CARBOHYDRATE RESEARCH
Volume 345, Issue 10, Pages 1452-1454Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2010.02.026
Keywords
Pyruvylated sulfated galactan; Codium fragile; Immunostimulating effect; RAW 264.7 cells
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A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1 beta, IL-6, IL-10 and TNF-alpha. Therefore, it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages. (c) 2010 Elsevier Ltd. All rights reserved.
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