Pyrroloiminoquinone and related metabolites from marine sponges

This review presents the structure, biological activity, biosynthetic studies and, where applicable, references to syntheses of 81 marine alkaloids containing either tetra-, hexa- or octa- hydrogenated variants of pyrrolo[ 4,3,2-de] quinoline, pyrrolo[ 4,3,2-de] pyrrolo[ 2,3-h] quinoline and pyrido[ 2,3-h] pyrrolo[ 4,3,2-de] quinoline core skeletons. The literature describing the isolation of pyrroloiminoquinones, and related metabolites, from marine sponges is littered with taxonomic inconsistencies and recent efforts to clarify the taxonomy of the sponges that produce this group of metabolites are discussed.