Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 12, Pages 1474-1478Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.04.029
Keywords
Gold glyconanoparticles; Glycosidases; Lectins; Multivalent presentation; Molecular recognition
Funding
- Spanish Ministry of Education and Science (MEC) [BQU02-03734, BQU2003-03550-C03-03, BFU2006-10288/BMC]
- CSIC
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Glyconanoparticles (GNPs) are water-soluble carbohydrate-functionalized gold nanoclusters with a promising potential to serve as versatile tools in studies ranging from basic chemical glycobiology to clinical applications. In this paper we evaluate the influence of ligand density and presentation on the recognition by protein receptors by examining the interaction of lactose-functionalized GNPs with two different galactose-specific carbohydrate-binding proteins: an enzyme, Escherichia coli beta-galactosidase, and a lectin, Viscum album agglutinin. The results suggest that the proper selection of ligand densities and spacers in GNP functionalization is an important requisite to match the topological requirements of the target receptor while escaping glycosidase degradation. (C) 2009 Elsevier Ltd. All rights reserved.
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