Journal
CURRENT PSYCHIATRY REVIEWS
Volume 1, Issue 1, Pages 1-9Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573400052953547
Keywords
Postmortem; human; CNS; microarray; 2D electrophoresis; schizophrenia
Categories
Ask authors/readers for more resources
High-throughput screening technologies such as microarrays and 2D electrophoresis are powerful analytical tools particularly suited to investigating the pathologies of complex diseases. Schizophrenia is now widely recognised as a complex disorder resulting from the interplay between genetic predisposition to the illness and the effects of yet to be identified environmental factors. Based the hypothesis that the outcome of the interaction between genetic predisposition and environmental factors act to produce changes in protein expression in the CNS to cause schizophrenia, a number of studies have used postmortem CNS and high throughput screening technologies to identify potential pathological processes that might be involved in the pathology of the disorder. This review attempts to place the current findings on gene and protein expression data in postmortem CNS from subjects with schizophrenia into a perspective that allows hypotheses on the cause of the disorder to be formulated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available