Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 1, Pages 98-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.09.027
Keywords
Hyaluronan; Conjugate; Camptothecin
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A novel methodology for making drug conjugates using hyaluronan as a carrier was developed. This strategy involves a completely regioselective two-step synthesis of 6-amino-6-deoxyhyaluronan, which is then easily functionalized with drugs through a Suitable linker. The case of hyaluronan-camptothecin Conjugates is described, making use of a simple succinate linker. The antitumor activity of new hyaluronan derivatives prepared is at present under evaluation. (C) 2008 Elsevier Ltd. All rights reserved.
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