Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 1, Pages 91-97Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.09.021
Keywords
Hyaluronan conjugate; Methotrexate; Drug delivery system
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Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy. (C) 2008 Elsevier Ltd. All rights reserved.
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