Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 11, Pages 1325-1331Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.04.026
Keywords
Cationized starch; Kappa-carrageenan; Interpolyelectrolyte complex; Ibuprofen; Matrix system; Controlled release
Funding
- National Research Council of Argentina (CONICET) [PIP 5467]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 06-14237]
- University of Buenos Aires [X137, B041]
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A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. (C) 2009 Elsevier Ltd. All rights reserved.
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