Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 2, Pages 198-203Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.10.019
Keywords
Nerium indicum; Galactooligosaccharide; Anti-angiogenesis activity
Funding
- National Natural Science Foundation of China (NSFC) [30670470, 30770484]
- High Tech Research and Development (863) Program [2006AA02Z102]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX1 -YW-R-1 8]
- The New Drug Discovery Research Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences [07G604F036]
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To discover drug candidates with anti-angiogenesis activity for cancer therapeutics, three galactooligosaccharides (OJ1-OJ3) were prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill. Their structures were characterized using sugar analysis, methylation analysis, and both 1D and 2D NMR spectroscopy, complemented by mass spectrometry. They were hexasaccharide (0J1), a pentasaccharide (OJ2), and an undecasaccharide (OJ3), which was a new linear galactan. Bioactivity testing in vitro showed that OJ2 and OJ3 significantly inhibited the HMEC-1 (human microvascular endothelial cell) cell tube formation. (C) 2008 Elsevier Ltd. All rights reserved.
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