Journal
CARBOHYDRATE POLYMERS
Volume 205, Issue -, Pages 63-71Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.09.068
Keywords
Trichoderma kanganensis; Polysaccharide; Structural characteristics; Anticancer activity; Antioxidant activity
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Funding
- Science and Technology Program of Shandong Province (Key Technology) [2015ZDJS04002]
- Major State Basic Research Development Program of China (973 Program) [2012CB822102]
- High Technology Research and Development Program of China (863 Program) [2012AA021501]
- Natural Science Foundation of Education Department of Anhui Province [KJ2018ZD025]
- projects of Anhui Province Key Laboratory of Biological Macro-molecules Research [LAB201801]
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A novel water-soluble polysaccharide designated as TPS was isolated from the fermentation mycelia of Trichoderma kanganensis. TPS had a weight-average molecular mass of 3.074 x 10(5) Da, and the monosaccharide composition was consisted of Man (45.5%), G1cA (5.5%), Glc (10%), and Gal (39%). The major backbone of TPS was -> 6-alpha-D-Galp-1 -> 5-beta-D-Manf-1 -> 5,6-beta-D-Manf-1 -> 5,6-beta-D-Manf-1 ->, and the side chains are alpha-D-Glcp-1 -> 4-alpha-D-Glcp-1 ->, beta-D-Galf-1 ->, and alpha-D-Glcp-1 ->. In addition, we demonstrated that TPS was non-toxic in normal cells (LO2 cells) and inhibited the proliferation of mouse colon cells (CT26 cells). TPS also showed free radical scavenging activity against hydrogen peroxide. Overall, these results suggested that TPS from Trichoderma kanganensis may have potential application in biomedical fields.
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