Journal
CARBOHYDRATE POLYMERS
Volume 201, Issue -, Pages 105-112Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.08.032
Keywords
Agarose; Laponite; Bioactive hydrogels; Nanocomposite; Nanosilicates
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Funding
- TUBITAK [116C031]
- European Union Marie Curie Co-Fund Brain Circulation Scheme Fellowship [116C031]
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This paper reports the synthesis of nanocomposite agarose hydrogels with improved bioactivity with the incorporation of anisotropic 2D nanosilicates (Laponite) to promote cell binding, growth and proliferation. Rheological measurements showed that the incorporation of nanosilicates slightly increased the gelation temperature (T-gel). The use of higher nanosilicate content at the constant agarose concentration improved the mechanical properties of the gels. Due to the non-swelling nature of agarose, the addition of nanosilicates did not result in any remarkable change in the swelling properties of the agarose gels, while collapsed agarose nanofibers were observed with the incorporation of nanosilicates. EDX analysis confirmed the presence of the embedded nanosilicates in the gel matrix. The existence of physical interactions between nanosilicate and agarose was demonstrated by FTIR over the shifting of Si-O stretching band to a lower frequency. The encapsulated NIH/3T3 fibroblast cells showed enhanced proliferation and spreading in the presence of nanosilicates.
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