Journal
CARBOHYDRATE POLYMERS
Volume 199, Issue -, Pages 649-660Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.07.018
Keywords
beta-Cyclodextrin; alpha(1 -> 2) Mannobioside; Homodimerization; Concanavalin A; Nitric oxide
Categories
Funding
- Spanish Ministry of Economy and Competitiveness [CTQ2013-48380-R, CTQ2017-90050-R]
- European Union through FP7-PEOPLE-2013-ITN project [608407]
Ask authors/readers for more resources
Two beta-cyclodextrin derivatives randomly appended on the primary face with both the nitric oxide (NO) photodonor 4-nitro-3-(trifluoromethyl) aniline and a mannose or alpha(1 -> 2) mannobioside residue are reported to construct targeted NO photoreleasing nanocarriers. 2D ROESY and PGSE NMR suggested supramolecular homodimerization in water by inclusion of the nitroaniline group into the facing macrocycle cavities. Isothermal titration calorimetry on their concanavalin A lectin binding showed an exothermic binding event to the lectin and an endothermic process during the dilution of the conjugates. Both alpha(1 -> 2) mannobioside and the nitroaniline moieties significantly enhanced the binding to the lectin. These effects might arise from a better fit within the carbohydrate-recognition site in the former case and a multivalent effect caused by homodimerization in the latter. Direct detection of NO by amperometric technique shows that both beta-cyclodextrin derivatives release this radical upon excitation with visible light with higher efficiency than the unfunctionalized NO photodonor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available