Journal
CARBOHYDRATE POLYMERS
Volume 200, Issue -, Pages 341-352Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.08.011
Keywords
pH-responsive hydrogel; Carboxymethyl cellulose; 2-Hydroxyethyl acrylate; Transdermal delivery system; Naringenin
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Funding
- Industry-University-Research Cooperation Technology Development Project of the Small and Medium Business Administration of Korea [C0541175]
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In this study, a pH-responsive hydrogel (cl-CMC-g-pHEA), based on carboxymethyl cellulose/2-hydroxyethyl acrylate, was prepared. Its physicochemical properties and applicability as a transdermal delivery system for naringenin (NRG) were investigated. The hydrogel was synthesized via radical polymerization; its structure was analyzed by FT-IR and H-1 NMR. The water loss amount was measured by using thermogravimetric analysis; a porous 3D network structure was confirmed by SEM. All hydrogels showed greater swelling ratio at pH 7.5 and 8.5 than at pH 5.5. Rheological and texture analyses indicated a stable gel network and that grafting and crosslinking density influenced the mechanical properties of the hydrogel. The release behavior of NRG from the hydrogel could be explained by the Fickian diffusion mechanism. The hydrogel system enhanced transdermal delivery of NRG. Therefore, this novel pH-responsive cl-CMC-g-pHEA hydrogel may be useful as a transdermal delivery system for NRG and has potential applications in the treatment of atopic dermatitis.
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