Journal
CARBOHYDRATE POLYMERS
Volume 106, Issue -, Pages 109-120Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.01.097
Keywords
Chitosan; Polyacrylic acid; Composite hydrogels; Synthesis; Characterization; Drug release
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Funding
- Council of Scientific and Industrial Research (CSIR)
- Department of Science and Technology (DST), Govt. of India
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Several composite hydrogels were synthesized by free radical crosslink copolymerization of acrylic acid (AA) and N' methylene bis-acrylamide (MBA) in the presence of chitosan (CS). During polymerization CS was incorporated in situ in the crosslinked polyacrylic acid gel to produce composite hydrogels. The structure and properties of the hydrogels were characterized by ETIR, C-13 NMR, DTA-TGA, XRD, swelling and diffusion characteristic and also network parameters. The loading and the in vitro release behaviours of theophylline and tinidazole model drugs were studied with these hydrogels. The wt% of CS and MBA and pH of the medium was found to strongly influence the drug release behaviour of the gels. Accordingly, the release rate of these two drugs was much faster at pH of 7.6 than at pH 1.5. (C) 2014 Elsevier Ltd. All rights reserved.
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