Journal
CARBOHYDRATE POLYMERS
Volume 104, Issue -, Pages 231-237Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.01.012
Keywords
Chitosan; Chitosan-TPP nanoparticles; Super-paramagnetic iron oxide; nanoparticles; Encapsulation; Magnetic resonance imaging (MRI)
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Funding
- National Research University Project under Thailand's Office of the Commission of Higher Education (CHE)
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Super-paramagnetic iron oxide nanoparticles (SPIONPs) were encapsulated at various concentrations within chitosan-triphosphate (SPIONPs-CS) nanoparticles using an ionotropic gelation method. The encapsulation of SPIONPs within CS nanoparticles enhanced their dispersion ability in aqueous solution, with all particles being lower than 130 nm in size and having highly positive surface charge. The SPIONPs-CS nanoparticles exhibited crystalline structure and super-paramagnetic behavior, as seen in non-encapsulated SPIONPs. The morphology of SPIONPs-CS nanoparticles showed that they almost spherical in shape. The effect of phantom environments (culture medium and 3% agar solution) on either T-1 or T-2 weighted MRI was investigated using a clinical 1.5T MRI scanner. The results revealed that 3% agar solution showed relaxation values higher than the culture medium, leading to a significant decrease in the MR image intensity. Our results demonstrated that the SPIONPs-CS nanoparticles can be applied as tissue-specific MRI contrast agents. (C) 2014 Elsevier Ltd. All rights reserved.
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