Journal
CARBOHYDRATE POLYMERS
Volume 111, Issue -, Pages 18-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.04.017
Keywords
Core-sheath nanofibers; Electrospinning; Cellulose acetate; Liposomes; Naproxen; Sustained drug release
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Funding
- National Natural Science Foundation of China [20974114, 21174150, 21174156]
- National Program on Key Basic Research Project of China (973 Program) [2011CB605604]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KJCX2-YW-H19]
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Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8 h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials. (C) 2014 Elsevier Ltd. All rights reserved.
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