Journal
CARBOHYDRATE POLYMERS
Volume 110, Issue -, Pages 62-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.03.065
Keywords
Thiolated chitosan; Thermo-sensitive hydrogel; Degradation; Protein release; Cytotoxicity
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Funding
- National Natural Science Foundation of China [51361130032, 81101348]
- Doctor Subject Foundation of the Ministry of Education of China [20120002130002]
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In order to get a water-soluble in situ gel-forming system, a thiolated chitosan, chitosan-4-thiobutylamidine (CS-TBA) conjugate was synthesized and used to replace the unmodified chitosan in the application of the in situ gel-forming system. A novel thermo-sensitive hydrogel was prepared based on CS-TBA/hydroxyapatite (HA)/beta-glycerophosphate disodium (beta-GP). The gel formation, rheological properties, morphology, degradation, cytotoxicity, as well as protein release process of the novel gel system were investigated in this study. The CS-TBA/HA/beta-GP gel showed a higher storage modulus (G') and loss modulus (G '') and a decreased bovine serum albumin (BSA) release rate which was maintained the protein release for a longer time compared with the unmodified chitosan (CS)/HA/beta-GP gel, due to the existence of thiol groups and/or disulfide bonds. The CS-TBA/HA/beta-GP gel has a porous structure with a uniform distribution of nano-hydroxyapatite, an appropriate degradation rate and low cytotoxicity, showing potential applications in drug delivery and tissue engineering. (C) 2014 Elsevier Ltd. All rights reserved.
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