Journal
CARBOHYDRATE POLYMERS
Volume 112, Issue -, Pages 746-752Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.06.052
Keywords
Chitosan oligosaccharide; Polycaprolactone; Copolymers; Redox-stimuli responsive; Micelles; Drug delivery
Categories
Funding
- Region Rhone-Alpes (Cluster de Recherche Chimie)
- Institut Carnot PolyNat
- Labex Arcane [ANR-11-LABX-0003-01]
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Chitosan-based amphiphilic graft copolymers are commonly obtained by modification of chitosan backbones with synthetic polymers hampering both bioactivity and biodegradability. In this work, we report the preparation of a series of chitosan oligosaccharide-grafted copolymers (PCL-g-COs) from coupling reactions between azide-pendent polycaprolactones (PCL-N-3) and reducing-end alkynyl-modified chitosan oligosaccharides (COs-alkynyl). The resulting PCL-g-COs self-organized in water into nanoscale micelles (R-h < 20 nm) having a COs shell and a PCL core. Locking of the core-micelles structure employing a disulfide-containing bis-alkyne cross-linker resulted in the formation of nano-vehicles which can be degraded in response to physiological (redox) stimuli. This feature was advantageously exploited to preferentially release an anticancer drug, doxororubicin, in response to the intracellular glutathione level. (C) 2014 Elsevier Ltd. All rights reserved.
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