Journal
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Volume 36, Issue 3, Pages 59-65Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
DOI: 10.3164/jcbn.36.59
Keywords
diallyl disulfide; polychlorinated biphenyls; drug metabolizing enzymes; cytochrome P450s; glutathione-S-transferase
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Polychlorinated biphenyls (PCBs) are persistent bioaccumulative toxicants. These synthetic organochlorinated compounds are well documented for their carcinogenic property, reproductive, neuro, hepato and developmental toxicities. Diallyl disulfide (DADS), a garlic organosulfur compound exerts its effect as a chemopreventive agent via the modulation of drug metabolizing enzymes which has led us to hypothesize that DADS could ameliorate the PCB-induced toxicity in liver and ventral prostate of the rats. In the present investigation, experimentally induced PCB toxicity elevated the activities of phase I enzymes and lipid peroxides level, whereas lowered the levels of phase 11 enzymes. Oral administration of DADS for 7 days modulated the levels of drug metabolizing enzymes and reduced the lipid peroxides level. These results suggest that PCBs can be readily metabolized by DADS administration through enhancing phase II enzymes thereby it reduces the toxic effects.
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