Journal
CARBOHYDRATE POLYMERS
Volume 111, Issue -, Pages 366-373Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.04.093
Keywords
Antimicrobial activity; Biocompatibility; Hydrogel; Skin substitutes; Wound healing
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Funding
- Portuguese Foundation for Science and Technology (FCT) [PEst-OE/EGE/UI4056/2011]
- Fundação para a Ciência e a Tecnologia [PEst-OE/EGE/UI4056/2011] Funding Source: FCT
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Healing enhancement and pain control are critical issues on wound management. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan (deacetylation degree 95%) and agarose. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The performance of the hydrogel in the wound healing process was evaluated through in vivo assays, during 21 days. The attained results revealed that hydrogel has a pore size (90-400 mu m) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 mu g/mL of chitosan. The improved healing and the lack of a reactive or a granulomatous inflammatory reaction in skin lesions treated with hydrogel demonstrate its suitability to be used in a near future as a wound dressing. (C) 2014 Elsevier Ltd. All rights reserved.
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