Magnetic core-shell chitosan nanoparticles: Rheological characterization and hyperthermia application

Stabilized magnetic nanoparticles are the subject of intense research for targeting applications and this work deals with the design, preparation and application ofspecific core-shell nanoparticles based on ionic crosslinked chitosan. The nanometric size of the materials was demonstrated by dynamic light scattering (DLS) and field emission scanning electron microscopy (FESEM) that also proved an increase of the size of chitosan nanoparticles (NPs) with the magnetite content. Steady oscillatory rheology measurements revealed a gel-like behavior of aqueous dispersions of chitosan NPs with concentrations ranging from 0.5% to 2.0% (w/v). The cytotoxicity of all the materials synthesized was analyzed in human fibroblasts cultures using the Alamar Blue and lactate dehydrogenase (LDH) assays. The measured specific power absorption under alternating magnetic fields (f =580 kHz, H= 24 kA/m) indicated that magnetic core-shell chitosan NPs can be useful as remotely driven heaters for magnetic hyperthermia. (C) 2013 Elsevier Ltd. All rights reserved.