Journal
CARBOHYDRATE POLYMERS
Volume 114, Issue -, Pages 190-195Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.07.075
Keywords
Lachnum polysaccharides; Carboxymethylation; Chronic renal failure; Antioxidant activity
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Funding
- National Natural Science Foundation of China [31470146]
- Fundamental Research Funds for the Central Universities [2012HGZY0020]
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Carboxymethylated polysaccharide CLEP-1b was prepared from a single component (LEP-1b) of Lachnum YM281 exopolysaccharides by molecular modification with a degree of substitution (DS) of 0.286. Infrared result proved that the carboxymethylation of LEP-1b succeeded and C-13 NMR result showed that the carboxymethyl group (-CH2COOH) was chemically linked to an oxygen (O) atom of the hydroxyl on C-3 of LEP-1b. LEP-1b could improve the histopathological status of kidney and significantly reduce the contents of serum creatinine (Scr) and blood urea nitrogen (BUN), and increase the contents of total protein and albumin. It could also enhance the activity of SOD, GSH-PX, CAT, GSH and decrease MDA contents in the nephridial and hepatic tissues. What's more, CLEP-1b showed more significant effects than LEP-1b at the same dosage. The research indicated that LEP-1b and CLEP-1b could mitigate the chronic renal failure of mice and the effects were closely associated with antioxidant activity. (C) 2014 Elsevier Ltd. All rights reserved.
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