Journal
CARBOHYDRATE POLYMERS
Volume 101, Issue -, Pages 517-523Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.09.078
Keywords
Chitosan; Methandrostenolone; Molecularly imprinted polymers; Solid-phase extraction; HPLC
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Funding
- Natural Science Foundation of Jiangsu Province, China [BK2008242]
- China Postdoctoral Science Foundation [20070420974]
- PAPD of Jiangsu Higher Education Institutions
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Chitosan molecularly imprinted polymers (CHI-MIPs) for selective extraction of methandrostenolone (MA) was synthesized by cross-linking of chitosan with epichlorohydrin in the presence of MA as the template molecule. Systematic investigations of the influences of template, functional polymer, cross-linker as well as porogen concentrations on the rebinding capacity of CHI-MIPs were carried out. Adsorption and kinetic binding experiments indicated that the synthesized CHI-MIPs had high adsorption and excellent affinity to MA. Solid-phase extraction (SPE) using the prepared CHI-MIPs as adsorbent was then investigated, and the optimum loading and eluting conditions for SPE of the MA were established. The optimized SPE procedure was used to extract the MA from several spiked samples and a good sample clean-up was obtained with the average recoveries ranged from 95.97 to 101.79%. (C) 2013 Elsevier Ltd. All rights reserved.
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