Journal
CARBOHYDRATE POLYMERS
Volume 93, Issue 2, Pages 430-437Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2012.12.051
Keywords
Dextran; Poly(epsilon-caprolactone); Diblock copolymers; Drug delivery
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Funding
- National Natural Science Foundation of China [51033002, 51273090]
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Amphiphilic dextran-b-poly(epsilon-caprolactone) diblock copolymers were synthesized with the purpose of preparing nanocarriers for doxorubicin (DOX), an anticancer drug. The Dex-b-PCL diblock copolymers were synthesized by end-to-end coupling of amino-terminated dextran and aldehyde-terminated poly(epsilon-caprolactone) and characterized by H-1 NMR spectra and gel permeation chromatography. The DOX-loaded Dex-b-PCL nanoparticles were prepared by a modified nanoprecipitation method and characterized by transmission electron microscopy and dynamic light scattering. In vitro release of DOX from DOX-Dex-b-PCL nanoparticles showed a sustained release manner with certain amount of burst release in the first 9 h. In vitro cytotoxicity test of DOX-Dex-b-PCL nanoparticles against SH-SY5Y cells showed that DOX is still pharmacologically active after drug loading. The fluorescence imaging results showed that DOX-Dex-b-PCL nanoparticles could be easily uptaken by SH-SY5Y cells. These results indicate that DOX-Dex-b-PCL nanoparticles may be a promising nanocarrier for DOX. (c) 2012 Elsevier Ltd. All rights reserved.
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