Journal
CARBOHYDRATE POLYMERS
Volume 95, Issue 1, Pages 366-370Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.03.020
Keywords
Hypericin; beta-Cyclodextrin polymer; Inclusion complex; Characterization
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Funding
- National Natural Science Foundation of China [21273195, 20973151, 20901065]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Foundation of the Educational Committee of Jiangsu Provincial General Universities Graduate Student Scientific Research Invention Plan
- Foundation of Jiangsu Provincial Key Program of Physical Chemistry in Yangzhou University
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A water-soluble inclusion complex of hypericin (HY) with beta-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by H-1 NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of beta-cyclodextrin (beta-CD) unit in CDP to HY was determined as 2:1. At 25 degrees C, the dissociated constant of HY-CDP was measured as 1.47 x 10(-7) mol L-1 by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the beta-CD drawbacks-such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application. (c) 2013 Elsevier Ltd. All rights reserved.
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