Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 19, Issue 3, Pages 253-266Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328205047219
Keywords
polyglycolic acid; scaffold; degradation; permeability
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Using a simple experimental setup, the hydraulic permeability of fibrous nonwoven polyglycohc acid (PGA) scaffolds is studied after different degradation durations in PBS. The hydraulic permeability of the scaffolds increased with the degradation time. After being incubated for about 4 weeks, the permeability of the scaffold begins to drop. It is noted that the PGA scaffold apparently begins to contract and cannot maintain its original shape after 4 weeks of degradation. These results underpin the understanding of the biotransport processes in the scaffolds during tissue engineering experiments.
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