Journal
ANNUAL REVIEW OF GENETICS
Volume 39, Issue -, Pages 615-651Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.39.073003.094210
Keywords
epigenetics; transcription; X chromosome
Categories
Funding
- NIGMS NIH HHS [R01 GM085186] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085186] Funding Source: NIH RePORTER
Ask authors/readers for more resources
In many multicellular organisms, males have one X chromosome and females have two. Dosage compensation refers to a regulatory mechanism that insures the equalization of X-linked gene products in males and females. The mechanism has been studied at the molecular level in model organisms belonging to three distantly related taxa; in these organisms, equalization is achieved by shutting down one of the two X chromosomes in the somatic cells of females, by decreasing the level of transcription of the two doses of X-linked genes in females relative to males, or by increasing the level of transcription of the single dose of X-linked. genes in males. The study of dosage compensation in these different forms has revealed the existence of an amazing number of interacting chromatin remodeling mechanisms that affect the function of entire chromosomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available