Journal
CARBOHYDRATE POLYMERS
Volume 97, Issue 1, Pages 165-171Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.04.034
Keywords
Agarose; Tryptophan; Hydrogel; Fluorescence; Genipin crosslinking
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Funding
- Ministry of New and Renewable Energy, New Delhi
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Microwave assisted facile synthesis of a fluorescent agarose-L-tryptophan hydrogel material employing carbodiimide chemistry (dicyclohexylcarbodiimide/4-dimethylaminopyridine; DCC/DMAP) has been described. The product formed fluorescent hydrogel at 1-1.5% (w/v), exhibiting fluorescence emission in water (lambda(max) 350 nm; 1 x 10(-4) M), which was significantly higher (ca. 65%) than that of tryptophan at the same concentration. Subsequently, the agarose ester was cross linked with the natural cross linker genipin to yield a blue hydrogel (G-Ag-Trp(Est)), confirming thereby the insertion of tryptophan moiety on to agarose backbone. Both the ester and cross linked hydrogels demonstrated gelling characteristics similar to agarose and were stable across a wide range of pH media (pHs 1.2, 7.0 and 12.5) under ambient conditions. These tryptophan containing fluorescent hydrogel materials may find applications in biomedical and pharmaceutical industries as potential radical scavengers and sensors. (C) 2013 Elsevier Ltd. All rights reserved.
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