Journal
CRITICAL REVIEWS IN IMMUNOLOGY
Volume 25, Issue 4, Pages 289-303Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.v25.i4.30
Keywords
brain; activation; virus; LCMV; autoimmunity; herpes stromal keratitis
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS048866] Funding Source: NIH RePORTER
- NINDS NIH HHS [R21 NS048866, NS048866-01] Funding Source: Medline
Ask authors/readers for more resources
It is generally accepted that both self and pathogen-specific T lymphocytes have the potential to mediate immunopathogenesis and contribute to a variety of human ailments. Despite this unfortunate tendency to induce tissue injury, these cells are guided by interactions with peptide-loaded major histocompatibility complexes (MHC) and adhere appropriately to a vital evolutionary constraint imposed by the host: specificity. More recently, a series of studies have demonstrated that bystander T cells of an irrelevant specificity can bypass peptide/MHC restriction and become active participants in immunopathology. This review critically evaluates the role of bystander T cells in immunopathogenesis and pathogen clearance in the periphery as well as the central nervous system and attempts to establish the likelihood of their participation in human disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available