Journal
CARBOHYDRATE POLYMERS
Volume 94, Issue 1, Pages 394-399Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.01.013
Keywords
N-(2,3-Dihydroxypropyl)-chitosan-cholic acid; Micelles; Paclitaxel; Drug delivery; Antitumor
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Funding
- Natural Science Foundation Project of CQ CSTC [jja10069]
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Self-assembled amphiphilic N-(2,3-dihydroxypropyl)-chitosan-cholic acid (DHP-CS-CHO) micelle was prepared as a carrier for paclitaxel. DHP-CS-CHO was synthesized by grafted small molecules cholic acid and glycidol onto primary amine group of chitosan, respectively. The DHP-CS-CHO formed uniform micelles (size = 212.4 +/- 3.1 nm) with a low critical micelle concentration (0.024 mg/ml) in PBS. Hydrophobic anticancer drug, paclitaxel (PTX), was easily encapsulated into chitosan derivative micelles by a dialysis method with loading efficiency up to 80%. The PTX loaded micelles released the drug in a sustained manner more than a week in PBS containing 0.1% (w/v) Tween 80 at 37 degrees C. In vitro antitumor experiment demonstrated that PTX loaded chitosan derivative micelles could inhibit MCF-7 cell growth and induce its apoptosis. These results suggested that DHP-CS-CHO may be a promising carrier for the anticancer drug PTX. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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